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Valproic Acid

Valproic Acid
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
Catalog No. T7064Cas No. 99-66-1
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Purity:99.49%
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Valproic Acid

Purity: 99.49%
Catalog No. T7064Alias VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic AcidCas No. 99-66-1

Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 g$50In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
Targets&IC50
HDAC1:0.4 mM
In vitro
METHODS: Esophageal squamous cell carcinoma (ESCC) cell lines TE9, TE10, TE11, and TE14 were treated with Valproic Acid (0.01-5 mM) for 72 h, and cell viability was assayed using MTT Assay.
RESULTS: Valproic Acid inhibited the viability of all ESCC cells in a dose-dependent manner. The IC50 values of Valproic Acid ranged from 1.02-2.15 mM in each cell line. [1]
METHODS: Mouse teratoma cells, F9, and human cervical cancer cells, HeLa, were treated with Valproic Acid (0.25-5 mM) for 4-24 h. The expression levels of target proteins were detected by Western Blot.
RESULTS: Only trace amounts of acetylated histones were detected in untreated F9 or HeLa cells. Treatment with Valproic Acid at concentrations as low as 0.25 mM increased the amount of acetylated histone H4, and significant acetylation was found with 2 mM Valproic Acid. [2]
In vivo
METHODS: To study the effects on Machado Joseph disease (MJD), Valproic Acid (200 mg/kg) was administered intraperitoneally to the CMVMJD135 mouse model five times per week for twenty-five weeks.
RESULTS: Chronic Valproic Acid treatment had limited effects on motor deficits in these mice, observed primarily in the late stages of locomotor swimming, beam swimming, rotational bar and spontaneous motor activity tests, and did not alter ATXN3 inclusion body loads and astrocyte proliferation in affected brain regions. [3]
METHODS: To assay antitumor activity in vivo, Valproic Acid (500 mg/kg, 10% DMSO 25% w/v Kleptose HPB buffer) was administered by gavage to BALB/c nude mice harboring the human AML tumor, Kasumi-1, once daily for twelve days.
RESULTS: Valproic Acid inhibited tumor growth in mice transplanted with Kasumi-1 cells. At the end of the experiment, the incidence of IR in the Valproic Acid group was 57.25%. [4]
AliasVPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
Chemical Properties
Molecular Weight144.21
FormulaC8H16O2
Cas No.99-66-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
5% DMSO+95% Saline: 5 mg/mL (34.67 mM), Working solution is recommended to be prepared and used immediately.
DMSO: 100 mg/mL (693.43 mM), Sonication is recommended.
H2O: 1 mg/mL (6.93 mM), Sonication and heating are recommended.
Solution Preparation Table
H2O/5% DMSO+95% Saline/DMSO
1mg5mg10mg50mg
1 mM6.9343 mL34.6717 mL69.3433 mL346.7166 mL
5 mM1.3869 mL6.9343 mL13.8687 mL69.3433 mL
5% DMSO+95% Saline/DMSO
1mg5mg10mg50mg
10 mM0.6934 mL3.4672 mL6.9343 mL34.6717 mL
20 mM0.3467 mL1.7336 mL3.4672 mL17.3358 mL
DMSO
1mg5mg10mg50mg
50 mM0.1387 mL0.6934 mL1.3869 mL6.9343 mL
100 mM0.0693 mL0.3467 mL0.6934 mL3.4672 mL

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